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No clarity on what defines an elevated risk to youth The Draft Guidance appears to segment the ENDS market into three broad flavor categories: Tobacco flavored Flavors posing low risk for youth appeal, such as menthol, mint, coffee, tea, and spices Flavors posing a high risk for youth appeal, such as fruit, candy, and dessert The Draft Guidance is vague about how these categories will be defined and how to characterize differences within and between the categories

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Their life expectancy loss associated with smoking, compared with the life expectancy of women with low SES who never smoke, is 10.1 years

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